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There is a 50 percent chance that geneticist Pierre Tardivel is carrying the gene for Huntington's Disease, a fatal disorder. That knowledge drives Pierre in his work on the Human Genome Project, an attempt by scientists to map human genes. But a strange set of circumstances--including a knife attack, the in vitro fertilization of his wife, and an insurance company plot to use DNA samples to weed out clients predisposed to early deaths--draw Tardivel into a story that will ultimately involve the hunt for a Nazi death camp doctor. Frameshift shows why the New York Times calls Robert J. Sawyer "a writer of boundless confidence."